Test Details: Immunohistochemical testing is carried out on resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody. Bcl-6 (B-cell lymphoma 6 protein) is a sequence-specific transcriptional repressor protein expressed in normal germinal centre B-lymphocytes with high proliferation rate and active somatic mutations. Bcl-6 is a marker for lymphomas of germinal centre origin such as follicular lymphoma (intra- and interfollicular cells), Burkitt’s lymphoma, majority of Hodgkin cells, and nodular lymphocyte predominant Hodgkin’s lymphoma. Mutations within the Bcl-6 gene are found in about 40% of diffuse large B-cell lymphoma.