Test Details: Immunohistochemical testing is carried out on biopsy/resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody .CD30 (Ki-1)—also known as lymphocyte activation antigen—is a transmembrane glycoprotein receptor and member of the tumour necrosis factor superfamily participating in the regulation of cell transformation, antibody response, and apoptosis. CD30 is normally expressed in activated B, T, and NK cells. One of the major utilities of CD30 in routine immunohistochemistry is to highlight Hodgkin cells and Reed-Sternberg cells of classical Hodgkin’s lymphoma. CD30 is also a diagnostic marker for anaplastic large cell lymphoma and primary mediastinal large B-cell lymphoma as well as high malignant types of systemic mastocytosis.