Test Details: Immunohistochemical testing is carried out on biopsy/resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody .MART-1 (also known as Melan A) is melanocyte antigen and member of the MAGE family involved in melanosomal maturation and regulation of pigmentation expressed in the endoplasmic reticulum of normal skin melanocytes and retinal cells and tumours derived from these cell types. MART-1 is one of the most common used melanoma markers expressed in more than 90% of melanomas. Nevertheless, MART-1 lacks the specificity for melanomas as it is found in other tumours such as adrenocortical and sex cord-stromal tumours.