Test Details: Immunohistochemical testing is carried out on biopsy/resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody .Synaptophysin is a transmembrane calcium-binding glycoprotein present as a major component of presynaptic vesicles. Synaptophysin is a wide-spectrum marker for neuroendocrine cells and tumours with neuroendocrine differentiation.