Test Details: Immunohistochemical testing is carried out on biopsy/resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody .TLE-1 is one of the four transcriptional repressors expressed during the embryogenesis involved in the regulation of haematopoiesis and epithelial and neuronal differentiation . TLE-1 is normally expressed in acinar cells of salivary glands. In routine immunohistochemistry, the expression of TLE-1 is mostly characteristic for synovial sarcoma; however, the overexpression of TLE-1 is also reported in different soft tissue tumours including endometrial stromal sarcoma, acral myxoinflammatory fibroblastic sarcoma, solitary fibrous tumour, epithelioid sarcoma, lipoma and liposarcoma, leiomyosarcoma, neurofibroma, malignant nerve sheath tumour, chordoma, mesothelioma, and undifferentiated pleomorphic sarcoma.