Test Details: Immunohistochemical testing is carried out on biopsy/resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody .IHC Melanosome is used to identify malignant melanoma. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphoma, sarcoma, spindle cell carcinoma and various mesenchymal neoplasm.