Test Details: Immunohistochemical testing is carried out on biopsy/resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody . Podoplanine is a transmembrane, oncofetal glycoprotein found on lymphatic endothelium, mesothelium and fetal testis. Used to determine presence of lymphatics in various conditions, presence of lymphovascular invasion. D2-40 is positive in dermatofibroma, seminoma, adrenocortical neoplasm and mesothelioma.