Test Details: The myeloproliferative disorder (MPD) also referred to as myleoproliferative neoplasms (MPN) are large group of relatively rare pathogenetically related diseases arising in the bone marrow and characterized by the proliferation of one or more myeloid cell line resulting in the increased numbers of relatively mature neoplastic cells in the peripheral blood. Polycythemia vera (PV), essential thrombocythemia (ET), idiopathic myelofibrosis (IMF) are three most common of BCR-ABL negative adults presenting with clinical, laboratory or pathological finding suggesting classic forms of PV, ET, or IMF. The samples are first tested for Jak2 Ex14 mutation- V617F and if negative tested for the Exon 12 mutations.