Test Details: Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). Factor V Leiden (FVL), or factor “5” Leiden, is a genetic mutation (change) that makes the blood more prone to abnormal clotting. It is the most common genetic predisposition to blood clots. The most common variant in the MTHFR gene is MTHFR C677T. The folate metabolism gene detection is mainly to detect sites of metabolism of folic acid related genes, to evaluate the individual’s folate metabolism ability, to achieve personalized supplementation of folic acid. This test is used to evaluate the cause of elevated homocysteine levels and to determine the risk of thrombosis or premature cardiovascular disease (CVD).