Test Details: The myeloproliferative disorder (MPD) also referred to as myleoproliferative neoplasms (MPN) are large group of relatively rare pathogenetically related diseases arising in the bone marrow and characterized by the proliferation of one or more myeloid cell line resulting in the increased numbers of relatively mature neoplastic cells in the peripheral blood. Polycythemia vera (PV), essential thrombocythemia (ET), idiopathic myelofibrosis (IMF) are three most common of BCR-ABL negative adults presenting with clinical, laboratory or pathological finding suggesting classic forms of PV, ET or IMF. Exon 12 mutations are typically found in PV patients who present with erythrocytosis. Screening of exon 12 mutations helps in identifying prognostically relevant clonal proliferation.