Test Details: Maternally Inherited Cardiomyopathy (MICM) is associated with maternally inherited mutation in mitochondrial DNA tRNAIle gene. MICM is associated with hypertrophic cardiopathy and causes a heart disease as opposed to most other mtDNA mutations. The age of onset and the clinical course of disease caused by mitochondrial mutations are highly variable due to mitochondrial heteroplasmy i.e. concurrent presence of wild type and mutant mitochondria in tissues and cells. The heteroplasmy also underlies the phenotypic variability characteristics of mitochondrial diseases.