Test Details: Protein C and S work together to help regulate and control blood clot formation by inactivating specific coagulation factors (factors V and VIII) that are required to generate and form blood clots. This has the net effect of slowing down clot formation. Therefore, if there is not enough protein C or S or they are not functioning normally, clot formation can go unchecked, possibly leading to excessive clotting. These conditions can range from mild to severe. There are two types of inherited protein C deficiencies: Type 1 is related to insufficient quantity. Type 2 is related to abnormal function and is less common than Type 1.