Test Details: The hormone 17-hydroxyprogesterone (17-OH progesterone) is produced by the adrenal glands. Along with special enzymes, 17-OH progesterone is converted to a hormone called cortisol. Cortisol is constantly released in varying amounts, but high levels are released during times of physical or emotional stress. Cortisol is also important in regulating metabolism and the immune system. High levels of 17-OH progesterone can indicate a condition called congenital adrenal hyperplasia (CAH).