Test Details: Hepatitis E virus (HEV) causes an acute, usually self-limited infection. This small, non-enveloped RNA virus is transferred from animal reservoir (e.g. hogs) to humans via the faecal-oral route. HEV-infected patients develop symptoms of hepatitis with appearance of anti-HEV IgM antibody in serum, followed by detectable anti-HEV IgG within a few days. Anti-HEV IgM may remain detectable up to 6 months after onset of symptoms. Anti-HEV IgM is the serologic marker of choice for diagnosis of acute HEV infection.