Test Details: Celiac disease is a life-long condition in which ingestion of gluten, the water insoluble wheat-gliadin and the prolamins in rye and barley, leads to chronic inflammation and damage of the small intestinal mucosa. Tissue transglutaminase (TTG) is an enzyme that has been identified as the major autoantigen in coeliac disease. IgA antibodies to TTG are specific serological markers in the diagnosis and follow-up of coeliac disease and Dermatitis Herpetiformis. TTG IgG antibodies are less specific, but are helpful markers in patients with IgA deficiency. This test is also useful in monitoring adherence to gluten-free diet in patients with IgA deficiency.