Test Details: Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disorder characterized by ataxia, choreoathetosis, dementia and psychiatric disturbance in adults and ataxia, myoclonus, seizures and progressive intellectual deterioration in children. Characteristic neuropathologic observations include degeneration of the dentatorubral and pallidoluysian systems of the central nervous system. This PCR-based assay is used to amplify across the region of the ATN1 (DRPLA) gene containing the CAG repeats.