Test Details: The B-cell gene rearrangement test detects IGH clonality from genomic DNA. B-cell lymphomas account for greater than 90% of non-Hodgkin lymphomas . During normal maturation, each mature B cell and plasma cell has unique rearranged heavy chain gene profile. A benign B-cell proliferation is characterized by polyclonal expansion of B-cells whereas a malignant process is often characterized by a clonal expansion of a predominant B-cell population. Diagnosis of B-cell lymphomas can often be made based on clinical, histologic and immunophenotypic data.